intestinal failure
Conditions
Interventions
daily oral/enteral fructose versus glucose for 4 weeks. Treatment periods will
be separated by a 4 week washout period. The dose of fructose will be
determined in a feasibility study in which we inv
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Treated by the TPN and IF Clinic at Amsterdam UMC • Ability to provide written informed consent (in Dutch) • Age of 18 years or older • Dependent on PN or iv fluids • Stable weight or stable amount of PN/iv fluids during the 3 months prior to start of the study • Adapted intestinal function,i.e. >=2 years after last small bowel resection (if applicable) • Duodenum and proximal jejunum in situ • Short bowel syndrome (
Exclusion criteria
Exclusion criteria: • Unable to read and understand the patient information letter and/or study procedures • Unable to tolerate oral or enteral nutrition • Ultrashort bowel ( 3 times upperlimit) • Severe metabolic acidosis • Severe gastrointestinal motility disorder • Known fructose intolerance • A high fructose-intake in regular oral and/or enteral diet (> 35 gram/day) • Contraindication for use of oral alanin and/ or glutamine • Contraindication for use of oral fructose • Body weight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary outcome is the citrulline generation test (CGT) which reflects Intestinal Enterocyte Function. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are microbiome composition and need for PN and iv fluids and intestinal absorption capacity of nutrients and fluid. | — |
Countries
Netherlands
Outcome results
None listed