degenerative joint disease Osteoarthritis Osteoarthritis joint disease
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Part 1 Eligible participants will meet the following criteria: (i) aged 18 years or older; (ii) never diagnosed with KOA; (iii) no pain in the ankles, knees, hips or low back for at least 6 months; (iv) no other diagnosed conditions that might impact mobility (e.g. inflammatory conditions, cancer, neurologic conditions); and (v) no contraindications to radiation exposure or MRI. Part 2. Eligible participants will belong to one of the following three populations: • Post-ACLR group: (i) aged 18-45 years; (ii) unilateral ACLR; between 12 and 18 months post-ACLR, with or without concomitant meniscal injuries; (iii) condition of index knee is stable; (iv) no complaints in contralateral knee (e.g., no pain, no history of injury); (v) no early KOA symptoms (no joint line tenderness, no pain while walking or climbing stairs); (vi) no radiographic OA (defined as Kellgren and Lawrence grade >= 2) on most recent radiograph if available (vii) no history of knee dislocation/multi-ligament injury. • Early knee OA group: (i) aged 45-65 years; (ii) body mass index (BMI) between 27 - 35 kg/m2; (iii) knee pain aggravated by weight-bearing activities for at least 6 months(iv) consulted a healthcare giver (general practitioner or physiotherapist) for knee complaints for the first time within the past 2 years, or never consulted a healthcare provider (v) no history of traumatic knee injury (defined as injury that required non-weight-bearing for >24 hours (e.g. fracture, dislocation, complete ligament rupture); (vi) no previous knee surgery. • No OA group, matched to early OA participants on sex and age: (i) aged 45-65 years; (ii) never diagnosed with KOA; (iii) no pain in the ankles, knees, hips or low back for at least 6 months; (iv) no history of traumatic knee injury (defined as injury that required non-weight-bearing for >24 hours (e.g. fracture, dislocation, complete ligament rupture); (v) no previous knee surgery.(vi) body mass index( BMI) lower than 27 kg/m2.
Exclusion criteria
Exclusion criteria: Part 1 (i)diagnosed with KOA; (ii) pain in the ankles, knees, hips or low back for at least 6 months; (iii) other diagnosed conditions that might impact mobility (e.g. inflammatory conditions, cancer, neurologic conditions); and (iv) contraindications to radiation exposure or MRI. Part 2 • Morning stiffness in the index knee lasting more than 30 minutes • Complaints of knee locking • Any other diagnosed or expected conditions that might impact the participant*s gait pattern (e.g., inflammatory conditions, cancer, neurologic conditions) • Musculoskeletal conditions affecting the ankles or hips, such as osteoarthritis or inflammatory arthritis • Body mass index > 35 kg/m2 • Contraindications to PET/MRI • Known renal insufficiency • Known allergy or contraindications to contrast agents • Contraindications to radiation exposure • Use of bisphosphonates • Unable to communicate in either Dutch or English
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Evaluate test-retest reliability of the biomechanical measurement protocol and processing pipeline. - Assess sensitivity of the biomechanical models to changes in model parameters. - Validate a 3D-2D image registration algorithm. - Assess the correlation between subchondral bone metabolism at baseline and progression of compositional or structural OA-related features after two years. - Explore associations among the data collected to generate hypotheses to inform future research. | — |
Primary
| Measure | Time frame |
|---|---|
| The association between biomechanical patterns at baseline with progression of structural OA-features on MRI after two years. | — |
Countries
Netherlands
Contacts
Public ContactE.H.G. Oei
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed