Molecular Analysis of Cutaneous T-cell Lymphoma Cells Isolated From Skin

Molecular Analysis of Cutaneous T-cell Lymphoma Cells Isolated From Skin - MACTIS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57121

Enrollment

100

Registered

2023-04-12

Start date

2024-11-25

Completion date

Unknown

Last updated

2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous lymphoma Skin lymphoma

Interventions

Not applicable.

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Age between 18-90 years Established diagnosis of MF, SS, LyP, or pc ALCL Skin lesions Not receiving therapy

Exclusion criteria

Exclusion criteria: Ongoing infection Patients younger than 18 years of age

Design outcomes

Primary

Measure	Time frame
The main study parameters are the prevalence of 1. genetic alterations (mutations, copy number alterations, translocations and DNA methylation) and 2.short term cultures as well as mouse models will be used to evaluate cytotoxic effect of selected drugs, including (but not limited to) anti CD30 antibodies, and inhibitors of JAK/STAT signalling.	—

Secondary

Measure	Time frame
Development of CTCL cell lines.	—

Countries

Netherlands

Contacts

Public ContactM.H. Vermeer

Leids Universitair Medisch Centrum

m.h.vermeer@lumc.nl2300 RC

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)