Disproportional fat-free mass loss, metabolic bariatric surgery, protein supplementation, resistance excercise Muscle loss, weight-loss surgery, protein supplementation, strenght training
Conditions
Interventions
During the 6-month intervention period, the control group follows standard care protocols, while standard care is complemented by additional protein intake, resistance training and counseling sessions
protein-rich food products into the daily 
intake pattern is made. Counseling sessions with dieticians are offered during the intervention periode to support participants with the dietary adjustments. 
Furthermore, participants in the intervention group will be invited to join supervised group sessions of resistance exercise at their NOK center once a week. Next to these sessions, patients are instr
 
Given the gastrointestinal and physical limitations postoperatively, the protein and resistance training interventions will commence three weeks after the surgical procedure. After the intervention pe
Measurements are performed before MBS, and 3-, 6-, and 12-months after MBS.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - A scheduled metabolic bariatric surgery procedure (i.e., a RYGB or sleeve gastrectomy) - Participation in the NOK care program - Able to understand and perform the study procedures
Exclusion criteria
Exclusion criteria: - Allergic or sensitive for milk proteins, or lactose intolerant - Diagnosed renal insufficiency - Diagnosed intestinal diseases influencing the uptake of protein (i.e., active inflammatory bowel disease, Crohn's disease) - Inability to perform any resistance training exercises (e.g., severe physical limitations) - Inability to comprehend scheduled procedures (e.g., language barriers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary outcome is the prevalence of disproportional FFM loss, defined as FFML/WL>30%. Changes in body composition, such as FFM loss and weight loss (WL) are determined by bioelectrical impedance analysis (BIA) in the total population (N=400); and by Dual Energy X-ray Absorptiometry (DXA) in a subgroup (n=100). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are body composition, (cardio)metabolic health, muscle strength, muscle function, cardiorespiratory fitness and health-related quality of life, and healthcare consumption. | — |
Countries
Netherlands
Contacts
Public ContactJ.H.M. Karregat
Radboud Universitair Medisch Centrum
Outcome results
None listed