Cerebral perfusion Microcirculation dysfunction
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18 years or older - Scheduled for diagnostic digital subtraction angiography (for the indication of Cerebral aneurysm, Tinnitus, Vasculitis, Follow-up after earlier embolization or neurosurgery) undergoing complete work-up of intracranial vessels (injection of at least left and right internal carotid artery) - Written informed consent obtained
Exclusion criteria
Exclusion criteria: - Any previous stroke or known neurological disorder associated with permanent structural brain abnormalities - An untreated arteriovenous malformation in the anterior cerebral circulation - Known history of: o connective tissue disease o significant stenosis of the common or internal carotid artery o dissection in the internal carotid artery - Hypercoagulability - Physical or psychiatric condition making it for the patient impossible or uncomfortable to lay still during the procedure - Visual pathology assessed during the diagnostic work-up that could interfere with the measurements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main parameters of interest are intracranial intra-arterial pressure, flow and resistance measurements of the left and right internal carotid, middle cerebral and vertebral arteries. Procedural safety outcomes will be documented. | — |
Secondary
| Measure | Time frame |
|---|---|
| The reproducibility (first vs. second measurement, and right vs. left), the influence of a different infusion rates of saline (low vs. high rate), and the influence of sensor position (distal vs. proximal) will be evaluated by linear regression analysis and with Bland-Altman plots. Hemodynamic data will be reported per case. | — |
Countries
Netherlands
Outcome results
None listed