VR-CAST: Forecasting outcomes in depression treatment with Virtual Reality.

VR-CAST: Forecasting outcomes in depression treatment with Virtual Reality. - VR-CAST

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57115

Enrollment

104

Registered

2024-02-12

Start date

2025-03-14

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression, Depressive disorder Depression

Interventions

Trier Social Stress Test (TSST)

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Clinical diagnosis of a depressive disorder according to the DSM-V diagnosed by the MINI: MDD, PDD or unspecified depressive disorder; 2. Participants have an IDS-SR score at baseline of >= 18; 3. Participants are recruited as new referrals or during intake at the UCP, including patients who will participate in the once-weekly and thrice-weekly group programs and patients receiving individual outpatient sessions; 4. Age 18-64.

Exclusion criteria

Exclusion criteria: 1. Previous exposure to the TSST (in vivo or VR version); 2. Photosensitive epilepsy or organic brain damage; 3. Insufficient command of the Dutch language; 4. Intellectual disability (estimated IQ

Design outcomes

Primary

Measure	Time frame
Primary baseline parameters (T0) include physiological stress response as measured by heart rate variability (HRV) in the frequency and time domains, salivary cortisol (CRT) and electrodermal activity (EDA) in response to a psychosocial stressor (TSST-VR); and psychological stress response as measured by the State-Trait Anxiety Inventory - short form (STAI-6). The primary endpoint is change in depression symptom severity measured by the Inventory of Depressive Symptomatology (IDS-SR).	—

Measure

Time frame

Primary baseline parameters (T0) include physiological stress response as measured by heart rate variability (HRV) in the frequency and time domains, salivary cortisol (CRT) and electrodermal activity (EDA) in response to a psychosocial stressor (TSST-VR); and psychological stress response as measured by the State-Trait Anxiety Inventory - short form (STAI-6). The primary endpoint is change in depression symptom severity measured by the Inventory of Depressive Symptomatology (IDS-SR).

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Secondary

Measure	Time frame
Secondary study outcomes include anxiety symptom severity measured by the Beck Anxiety Inventory (BAI) and psychosocial functioning measured by the Interpersonal Relationships and Social Role subscales of the Outcome Questionnaire (OQ-45). Other study parameters include real-life stress response measured with EMA and wearable sensors, and potential factors moderating the relationship between stress response and depressive symptoms (family history of depression, stressful life events, personality traits and coping styles). Secondary parameters are described in more detail in the research protocol.	—

Measure

Time frame

Secondary study outcomes include anxiety symptom severity measured by the Beck Anxiety Inventory (BAI) and psychosocial functioning measured by the Interpersonal Relationships and Social Role subscales of the Outcome Questionnaire (OQ-45). Other study parameters include real-life stress response measured with EMA and wearable sensors, and potential factors moderating the relationship between stress response and depressive symptoms (family history of depression, stressful life events, personality traits and coping styles). Secondary parameters are described in more detail in the research protocol.

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Countries

Netherlands

Contacts

Public ContactJ.A. Dean

Universitair Medisch Centrum Groningen

vr-cast@umcg.nl0652905051

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Jun 27, 2026