Ovarian carcinoma
Conditions
Interventions
Assessing the in vitro effect of Beta-glucan, Lipopolysaccharide, Mifamurtide, Heat-killed Candida an Bacillus Calmette-Guérin on trained immunity in women with ovarian carcinoma and women with benign
Sponsors
Catharina Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects should be at least 18 years old and mentally competentPatients with ovarian carcinoma undergoinig primary debulkingPatients with ovarian carcinoma undergoinig intervaldebulkingPatients without a malignancy undergoing surgery for benign gynaecological conditionsPatients planned for an exploratory laparotomy with frozen section
Exclusion criteria
Exclusion criteria: Known inflammatory or infectious diseases or an immunosuppressive statusUsing medication interfering with the immune systemSevere comorbidities: other active malignancy (except for basal cell carcinoma and other in situ carcinomas)Serious psychiatric pathologyA self-reported alcohol consumption of >21 units per weekMentally incompetentPregnant or breastfeedingBMI >/= 32 kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transcriptional, epigenetic and functional signature of circulating and tissue (BM and spleen) monocytes and myeloid progenitors of ovarian cancer patients compared to women with bening gynaecological disease undergoing surgery for this problem | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Contacts
Public ContactJ.M.J. Piek
Catharina Ziekenhuis
Outcome results
None listed