Nutritionele status (en dus preventief) Bioavailability uptake kinetics
Conditions
Interventions
Intervention: Study subjects will receive one of the 2 fish oil supplements in
a randomized order
Sponsors
Vitux AS
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Apparently healthy adults (18 - 50 yrs); - Body mass index (BMI) >=18.5 and
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Having a disease that may interfere with the outcomes of this study, such as a known metabolic, gastrointestinal, inflammatory or chronic disease (such as anaemia, diabetes, hepatitis, hypercholesterolemia, cardiovascular disease), as judged by the medical investigator; - Having a history of medical or surgical events that may significantly affect the study outcome, including: inflammatory bowel disease, pancreatitis, ulcers, gastrointestinal or rectal bleeding; major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection; known or suspected gastrointestinal disorders, colon or GI tract cancer; - Use of medication that may interfere with the study outcomes, including gastric acid inhibitors, laxatives, and lipid lowering drugs, as judged by the medical supervisor; - Anaemia (Haemoglobin (Hb) values 21 (women) or >28 (men) glasses of alcoholic beverages per week; - Reported to follow or having planned a slimming or medically prescribed diet; - Use of recreational drugs; - Current smokers, or stopped smoking in the last 3 months before study start; - Insufficient proficiency in Dutch to understand information brochure and questionnaires - Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before test day 1 of this study and during the study period; - Being an employee of the department Food, Health & Consumer Research Wageningen Food & Biobased Research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the sum of EPA and DHA plasma levels in venous blood samples collected at baseline (t=-15min and 0) and at t=30, 60, 90, 120, 150, 180, 240, 360, 540, and 720min (obtained from cannula) and 24hours (obtained via vena punction) after consumption of the different fish oil supplements. | — |
Countries
Netherlands
Outcome results
None listed