Systematic Multimodal Approach for Biomarkers And Bulbar assessments In Early-diagnosed SMA

Systematic Multimodal Approach for Biomarkers And Bulbar assessments In Early-diagnosed SMA - SMA BABIES

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57032

Enrollment

Registered

2024-04-10

Start date

2025-04-15

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SMA Spinal muscular atrophy SMA

Interventions

EMG

Eligibility

Age

No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Homozygous deletion of SMN1 detected by the national newborn screening program Treatment-naïve concerning SMN- modulating therapies Given oral and written informed consent by the legal representative; legal representative are able to understand the Dutch language and information adequately

Exclusion criteria

Exclusion criteria: Comorbidities that interfere with performing EMG (CMAPscan) Strong apprehension against the performance of EMG

Design outcomes

Primary

Measure	Time frame
Motor unit number at the median nerve	—

Secondary

Measure	Time frame
Motor unit number at the peroneal nerve Motor unit size Ratio between small and large motor units Motor unit curve pattern (smooth vs gapped)	—

Countries

Netherlands

Contacts

Public ContactRI Wadman

Universitair Medisch Centrum Utrecht

smaonderzoek@umcutrecht.nl0887555555

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Mar 20, 2026