Effects of sitting interruption frequency on cognitive function and glucose metabolism: A randomized, controlled cross-over study involving young sedentary adults

Effects of sitting interruption frequency on cognitive function and glucose metabolism: A randomized, controlled cross-over study involving young sedentary adults - Frequency of Interrupting Sitting and Cognitive Function

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON57014

Enrollment

Registered

2024-09-09

Start date

2024-10-03

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breaking up sitting with walking breaks Breaking up sitting and cognitive function glucose metabolism

Interventions

Participants will complete four conditions in a randomized, counterbalanced order: SIT (uninterrupted prolonged sitting without any interruptions), SBR (walk 1 minute every 10 minutes), MBR (walk 3

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Men and women aged 18-35 years; - BMI between 18.5-24.9 kg/m2; - SB, i.e. sitting for an average of at least 9 hours per day assessed by activPAL; - Physically inactive, i.e. engaging in exercise for less than 2 to 3 times per week; - Stable body weight (weight gain or loss

Exclusion criteria

Exclusion criteria: - Current smoker, or smoking cessation within the last 12 months; - Individuals diagnosed with diabetes, cardiovascular disease, or other significant medical conditions, including epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, autoinflammatory diseases, and rheumatoid arthritis; - Not sedentary, i.e. sitting for less than an average of 9 hours per day assessed by activPAL; - Physically active, i.e. engaging in exercise for more than 3 times a week; - Abuse of drugs; - Use medication to treat BP, lipid, or glucose metabolism; - Pregnant females.

Design outcomes

Primary

Measure	Time frame
The primary outcome is mental flexibility assessed using the computer-based Trial Making Test.	—

Secondary

Measure	Time frame
The secondary outcomes, as further measure of cognitive function, are interference and memory respectively assessed by the computer-based Stroop task, n-Back Test and attention measured by paper-based d2 attention test. Moreover, as secondary outcomes variables characterizing the glucose metabolism will be measured (e.g., plasma glucose, and serum insulin). Serum brain-derived neurotrophic factor (BDNF), serum triacylglycerol (TAG), and mood are the exploratory outcomes.	—

Measure

Time frame

The secondary outcomes, as further measure of cognitive function, are interference and memory respectively assessed by the computer-based Stroop task, n-Back Test and attention measured by paper-based d2 attention test. Moreover, as secondary outcomes variables characterizing the glucose metabolism will be measured (e.g., plasma glucose, and serum insulin). Serum brain-derived neurotrophic factor (BDNF), serum triacylglycerol (TAG), and mood are the exploratory outcomes.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)