Gilles de la Tourette syndrome (GTS Obsessive-compulsive disorder (OCD)
Conditions
Interventions
The patients will be treated with a low frequency 1 Hz rTMS protocol on the
(pre)supplementary motor area (SMA). rTMS treatment will be given for 20 times,
once a day, 5 days/week, for 4 weeks. We w
Sponsors
Amsterdam UMC
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Age 12 to 18 years old; 2. Diagnosed with Obsessive-Compulsive Disorder (OCD) and/or Gilles de la Tourette Syndrome (GTS); based on a semi-structured interview such as the Structural Clinical Interview for DSM 5 Childhood Disorders (SCID 5 Junior). 3. Nonresponse (defined as
Exclusion criteria
Exclusion criteria: 1. Intracerebral metal implants (e.g. cochlear implant, brain stimulator); 2. (History of) epilepsy or epilepsy in a first degree relative; 3. Any other neurological disorder with seizure risk; 4. Acute suicidal ideations; 5. Bipolar disorder; 6. Current disorder in substance abuse; 7. Any known other serious somatic health problem; 8. Pregnancy. rTMS contraindications 1. History of epileptic seizures or epilepsy in a first degree relative; 2. Cochlear implants; 3. Implanted neurostimulators; 4. Cardiac demand pacemakers; 5. Implanted defibrillator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of rTMS added to treatment-as-usual, conceptualized as the practical and personal preferences and obstacles for performing the rTMS, possible side effects and drop-out rates (qualitative interview & experiences of researchers). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Symptoms of OCD (obsessive-compulsive behavior score & CY-BOCS) - Symptoms of GTS (tic behavior score & YGTSS) Other study parameters - Clinical impression of outcome (CGI) - Session results (SRS/ORS) - Symptoms of anxiety (SCARED) - Symptoms of depression (CDI-2) | — |
Countries
Netherlands
Outcome results
None listed