Muscle anabolism Muscle health
Conditions
Interventions
Over a 10-d period, participants will consume a controlled omnivorous diet (in
which ~60% of total protein intake will come from meat based products) followed
by a controlled meat-free (i.e. plant-b
Sponsors
Universiteit Maastricht
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or Female sex Aged between 65 and 85 year inclusive BMI between 18.5 and 30 kg/m2 inclusive
Exclusion criteria
Exclusion criteria: - Not willing to consume meat/animal-derived food products during the study period - Any food allergies (e.g. milk, gluten, etc.) - Participating currently or in the 3 months prior to the study in a structured progressive exercise program. - Smoking - History of diseases or disorders, and/or medication use which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the study team and responsible physician) - Donated full blood 3 months prior to test day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in muscle protein synthesis rates in the non-exercised leg, between the plant-based diet and the omnivorous diet, expressed as FSR (%/day). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Difference in muscle protein fractional synthesis rates in the exercised leg, between the plant-based and omnivorous diet (calculated similar to rest, but using muscle biopsy from exercised leg) - Plasma fasting glucose - Plasma fasting insulin - Blood lipid profile - Blood pressure | — |
Countries
Netherlands
Outcome results
None listed