MOnitoring NUtritional COnsequences of Obesity Treatment on women's health and transgenerational effects for healthier future generations.

MOnitoring NUtritional COnsequences of Obesity Treatment on women's health and transgenerational effects for healthier future generations. - MONUCO

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56975

Enrollment

1150

Registered

2024-04-08

Start date

2025-01-28

Completion date

Unknown

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

muscle quality

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the cohort:  - Female at birth  - Aged 18-55 years of age - Living with obesity (BMI => 27 kg/m^2 + comborbidity OR BMI => 30 kg/m^2) - Approved for obesity treatment in one of the participating hospitals. - Undergoing bariatric surgery (RYGB OAGB, or SG) - Receiving obesity medication (any type) under medical supervision with  BMI => 27 kg/m^2) - For those undergoing MRI, DEXA and quantitative ultrasound scan: Willing to  be informed about incidental findings of pathology and approving of reporting  this to their general physician. Additional criteria for the (integrated) birth cohort: - Being pregnant, or having pregnancy wish - Age 18-45 years of age - Having received prior obesity treatment (either surgical (RYGB, SG) or  pharmacological, at least 4 months)

Exclusion criteria

Exclusion criteria: Exclusion criteria for the cohort: - Male sex at birth - Aged <18 or >55 years of age - BMI <27 kg/m^2 - Not able to read and/or write Dutch - Undergoing a revisional or secondary bariatric procedure (excluding previous  gastric banding) - Malnutrition due to other chronic condition, specifically malignancy,  substance abuse - (mental) condition that makes it impossible to fill out a questionnaire  correctly. Additional criteria for the (integrated) birth cohort: - Aged <18 or >45 years of age - >25 weeks of gestation - Multiple pregnancy - Reversal of the bariatric procedure

Design outcomes

Primary

Measure	Time frame
Main parameters are changes in nutrient intake and status as well as muscle mass and bone mineral density. Muscle strength, muscle fat infiltration and bone marrow adipose tissue are main outcomes of the subgroup. Main endpoints of the birth cohort are foetal growth and child development.	—

Secondary

Measure	Time frame
Secondary parameters are lifestyle factors and parameters of the endocrine and reproductive systems (i.e., menstrual complaints, thyroid function and hormonal changes).	—

Countries

Netherlands

Contacts

Public ContactA.M. Berendsen

Wageningen Universiteit

monuco.studie@wur.nl+31 6 13279834

Outcome results