postoperative cerebral dysfunction Postoperative cognitive decline (POCD)
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Planned for elective thoraco-abdominal aortic aneurysm repair that also have an ELD as part of their routine clinical care at Radboudumc
Exclusion criteria
Exclusion criteria: - Disease states associated with a state of neuroinflammation: brain or spinal surgery within the last 6 months, meningitis or brain infection within the last 6 months, presence of a CSF catheter or shunt, presence of known brain tumor, brain injury (e.g., stroke, or subarachnoid hemorrhage) within the last 12 months, moderate-severe brain trauma in previous medical history, chronic active alcoholism or substance use. - Pre-existing dementia or neurodegenerative disease - Cognitive impairment interfering with the ability to understand informational study material. - Chronic (>2 weeks) use of immunosuppressive agents (see table 3.3.A, below) - Concomitant diseases resulting in severe immunosuppression (e.g., HIV, hematological malignancies) - Patients that do not speak Dutch or analphabetic patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint are biological pathways and markers based on transcriptomic and epigenetic data, with patients divided into two groups based on cognitive assessment after 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Primary endpoint are biological pathways and markers based on transcriptomic and epigenetic data, with patients divided into two groups based on cognitive assessment after 12 months. | — |
Countries
Netherlands
Outcome results
None listed