FUNCTIONAL GENOMIC RESEARCH IN OSTEOARTHRITIC CARTILAGE

FUNCTIONAL GENOMIC RESEARCH IN OSTEOARTHRITIC CARTILAGE - De *Research osteoArthritic Articulair Cartilage* (RAAK) study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56915

Enrollment

400

Registered

2009-02-16

Start date

2009-02-20

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cartilage degeneration osteoarthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients above 40 years of age that are eligable for a total knee or hip replacement. - Joint replacements is due to end stage osteoarthritis

Exclusion criteria

Exclusion criteria: -Patients that are obtaining a total knee or hip replacement due to other causes then osteoarthritis

Design outcomes

Primary

Measure	Time frame
In order to assess functional effects of OA susceptibility genes in the relavant disesed tissue in comparison to blood by: Monitoring of RNA expression profiles in diseased tissue and blood. Differential allelic expression of susceptibility alleles in diseased tissue and blood	—

Secondary

Measure	Time frame
Increased knowledge on the OA etiology will allow, in the future, new drugable targets, better prevention, prognosis and disease management.	—

Countries

Netherlands

Outcome results