Metabolic Dysfunction associated steatohepatitis (MASH) Metabolic fatty liver disease
Conditions
Interventions
None listed
Sponsors
Zuyderland
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: subject must be eligible for abdominal surgery (bariatric, gallbladder or other) and between 18 and 75 years of age. The additional inclusion criterion for the control group will be BMI25.
Exclusion criteria
Exclusion criteria: - Evidence of MASLD (based on biopsy or fibroscan measurements) for lean (BMI 2 per day for women; >3 per day for men - Drug abuse - Known viral hepatitis or other infection - Hepatic cancer - Elevated CRP levels (>10) - Diabetes mellitus type 1 or other autoimmune diseases - Use of anti-inflammatory drugs (specifically corticosteroids) - For patients without type 2 diabetes: use of anti-diabetes drugs due to their known effect on inflammation (e.g. metformin, GLP1 mimetics) - - Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Immune cell signature in blood, AT and liver - Inflammatory mediators in blood, AT and liver - Liver phenotype: MASLD activity score (histology), composite scores (MASLD fibrosis score, FIB-4) and ALAT/ASAT plasma levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Potential confounders: - BMI, waist circumference - Metabolic profile: fasting glucose, HbA1c, fasting insulin, HOMA-IR, plasma lipids - Age - Sex - Ethnicity - Alcohol consumption - Smoking - Medication use - Blood pressure | — |
Countries
Netherlands
Contacts
Public ContactE.G. Boerma
Zuyderland
Outcome results
None listed