head and neck cancer head and neck squamous cell carcinoma
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients are scheduled for panendoscopy or surgery for squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, larynx or cervical part of oesophagus. 2. Patients must have sufficient knowledge of the Dutch language to understand the meaning of the study as described in the patient information. 3. Patients must have the mental capacity to understand the meaning of the study as described in the patient information. 4. Patients must give written informed consent. 5. Age of the patients should be >18. An upper limit of age will not be applied. Elderly patients who are fit enough to undergo surgery in the head and neck area are not likely to encounter negative effects of the extra procedures that will be applied as part of the study.
Exclusion criteria
Exclusion criteria: Too limited size of the carcinoma according to the treating physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to define the TiME in the various anatomical and molecular HNSCC subclasses (HPV-related, non-HPV related CNA-other and non-HPV related CNA-quiet) and to comprehend which molecular and/or immune mechanisms relate with prognosis and response to therapies. Differences in the TiME will be assessed by flow cytometry, multiplexed immunohistochemistry, DNA/RNA sequencing, spatial transcriptomics, primary tumor cultures and functional immune assays. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints in our study will be TiME characteristics which are related to: 1. Immunotherapy response 2. Clinical outcome / overall survival 3. New immune suppressive mechanisms in HNSCC | — |
Countries
Netherlands
Outcome results
None listed