Endocriene aandoeningen van de bijnier/gonadale functie/perifere weefsels Excessive hair growth in women hirsutism
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Premenopausal women (18-40 years) with hirsutism: - Ability to provide informed consent; - Ability to speak and understand Dutch; - The presence of hirsutism. Healthy premenopausal women (18-40 years): - Ability to provide informed consent; - Ability to speak and understand Dutch; - Consider themselves healthy; no signs of hirsutism, hyperandrogenism or other endocrine pathologies.
Exclusion criteria
Exclusion criteria: Premenopausal women (18-40 years) with and without hirsutism: - Primary ovarian insufficiency (POI) or premature ovarian failure (POF); - Pregnancy; - Any of the following medications: o Oral contraceptives o Anocrine/danazol; o Minoxidil; o Fluoxetine; o Celestone; o Dexamethasone; o Hydrocortisone; o (Methyl)prednisolone; o Prednisone; o Spironolactone; o Flutamide; o Finasteride; o Cimetidine; o Anabolic steroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Conjugated androgen metabolites: 3a-diol-3G, 3a-diol-17G, ADT-G - 3G/17G-ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| - Results of the psychological questionnaire - HOMA-index (serum measurement) - HbA1c, fasting insulin and glucose - Lipid profile (serum total cholesterol, LDL, VLDL, HDL, triglycerides) - Liver enzymes (serum ALP, ALT, AST, GGT, ELF) | — |
Countries
Netherlands
Outcome results
None listed