Non-small cell lung cancer non-small-cell lung cancer
Conditions
Interventions
All treatments are 5x6 Gy to all targets. Patients receive an increasing primer
shot treatment break. In the 3+4 phase, the break between the first and the
second radiotherapy fraction is: 1, 2 and
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age >= 18 years • NSCLC (either pathology proven or sufficient clinical suspicion to be treated as NSCLC), referred for palliative radiotherapy of at least the primary tumor site (to eleviate or prevent symptoms like shortness of breath, coughing, pain or hemoptysis). • NSCLC, stage 2-4 • WHO performance score 0*2. • Provision of signed, written and dated IC prior to any study specific procedures.
Exclusion criteria
Exclusion criteria: • Interstitial lung disease • Treatment with vascular endothelial growth factor receptor (VEGFR) inhibitors • Prior thoracic radiotherapy (>20 Gy EQD2 a/b 3) overlapping with the current planning target volume • Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is whether patients finish the radiotherapy schedule as planned (completion of all 5 fractions and two or less additional unplanned days between fractions). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are tumor response at the end of treatment and 3 months thereafter, and acute toxicity. | — |
Countries
Netherlands
Outcome results
None listed