Bioavailability of omega-3 fatty acid absorption in blood, immune function, Immune response
Conditions
Interventions
During each postprandial test day, the subjects receive one of the 3
omega-3-rich supplements (one of 2 types of algae oil supplements or a fish oil
supplement control) in capsule form (6 capsules p
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Apparently healthy men and women; - Age >= 50 years - Body mass index (BMI) >=18.5 and
Exclusion criteria
Exclusion criteria: - Having a disease that may interfere with the outcomes of this study, such as a known metabolic, gastrointestinal, inflammatory or chronic disease (such as anaemia, diabetes, hepatitis, cardiovascular disease), as judged by the medical investigator; - Having a history of medical or surgical events that may significantly affect the study outcome, including: Inflammatory bowel disease, hepatitis, pancreatitis, ulcers, gastrointestinal or rectal bleeding; major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection; known or suspected gastrointestinal disorders, colon or GI tract cancer; - Use of medication that may interfere with the study outcomes, including gastric acid in-hibitors or laxatives, as judged by the medical supervisor. - Anaemia (Haemoglobin (Hb) values 21 (women) or >28 (men) glasses of alcoholic beverages per week; - Reported weight loss or weight gain of more than 3 kg in the month prior to pre-study screening, or intention to lose weight during the study period; - Reported to follow or having planned a slimming or medically prescribed diet; - Use of drugs; - Current smokers, or stopped smoking in the last 3 months before study start; - Insufficient proficiency in Dutch to understand information brochure and questionnaires; - Participation in any clinical trial including blood sampling and/or administration of sub-stances up to 30 days before test day 1 of this study and during the study period; - Being an employee of the department Food, Health & Consumer Research or Food Quality and Design of Wageningen Food & Biobased Research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the functional immune response (ratio pro- and anti-inflammatory markers) measured in isolated PBMCs, collected at 0 hours (baseline), 4 hours, and 8 hours after consumption of the omega-3-rich supplements, and after 1-week exposure to the supplements. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are the DHA levels in blood and fatty acid levels in plasma and PBMCs, taken before and after the consumption of omega-3-rich supplements. | — |
Countries
Netherlands
Contacts
Public ContactT Hoppenbrouwers
Wageningen Universiteit
Outcome results
None listed