Huntington's Disease and pain
Conditions
Interventions
n.v.t.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, an Adult- Onset Huntington's Disease (HD) subject must meet the following criteria: 1. Genetically and clinically confirmed AoHD patients (>= 21 years, CAG repeats >= 36; DCL of 4). 2. Good general health apart from having HD. Note: Patients with chronic illness (e.g. hypertension) will be eligible if the illness is stable and well-controlled according to the investigator that will not impact the primary objectives of the study. 3. Able to give written informed consent.
Exclusion criteria
Exclusion criteria: Potential Adult-Onset Huntington's Disease subject who meets any of the following criteria will be excluded from participation of this study: 1. Juvenile and Pediatric Huntington*s Disease (age at onset <21 years). 2. Patients in the late stage of the disease (UDHRS-TFC score < 3). 3. Have medical, psychiatric, or other conditions (other than HD) that, according to the investigator, may compromise the patient*s ability to understand the patient information sheet, to give informed consent, to comply with all study requirements, or to perform study assessments .(other than HD). 4. Have a history of (in the past year) or current (ab)use of any drug, alcohol or medication that, in the opinion of the investigator, may seriously impact interfere with the primary objectives of the study, according to the investigator. 5. The presence of any sensorimotor neuropathy or any another disturbance significantly disturbing the somatosensory systems), based on medical history and/or clinical examination, that can interfere with the pain testing battery. 6. Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The feasibility of the different pain test batteries will be evaluated using a screening tool including different items and cut-off scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| The potential disturbances in the processing of pain in terms of facial expression will be measured by the investigators by using the facial expression items of the PAIC15. In addition, the intra- and interrater reliability of the facial descriptors, body movements and vocalization items of the PAIC15 will be assessed. An exploratory objective is to assess the agreement (measurement error), in other words how close scores for repeated measures are, will be assessed for each outcome included in this study (e.g. facial response [PAIC15], pain inhibition and facilitation). | — |
Countries
Netherlands
Contacts
Public ContactG.P. Sprenger
Leids Universitair Medisch Centrum
Outcome results
None listed