velopharyngeal insufficiency, hypernasal speech hypernasal speech
Conditions
Interventions
MRI scan
Sponsors
Amsterdam UMC
Eligibility
Age
2 Years to 64 Years
Inclusion criteria
Inclusion criteria: - >4 years of age - History of non-syndromic cleft palate (CP) - No history of speech improving surgery - Hypernasality for study group; no hypernasality for control group - Informed consent - Patient <12 years of age: informed consent required from parent(s)/legal guardian(s) - Patients 12-16 years of age: informed consent required from both patient and parent(s)/legal guardian(s) - Patient >16 years of age: informed consent required from patient - Patient can be well instructed with regard to the MRI scan
Exclusion criteria
Exclusion criteria: - <4 years of age - No history of non-syndromic cleft palate (CP) - History of speech improving surgery - No hypernasality for study group; hypernasality for control group - No informed consent - Patient cannot be well instructed with regard to the MRI scan Non-removable orthodontic device Any exclusion criteria regarding the MRI scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in MRI parameters of velopharyngeal anatomy between patients with cleft palate and velopharyngeal insufficiency (VPI), and individuals with cleft palate without VPI.The correlation between MRI parameters of velopharyngeal anatomy and the outcomes of clinical speech evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The feasibility of velopharyngeal MRI scans. The correlation between MRI parameters of velopharyngeal anatomy and the outcomes of PROMs, nasendoscopy, nasometry, mirror test, and oral inspection. | — |
Countries
Netherlands
Contacts
Public ContactJJ Peters
Amsterdam UMC
Outcome results
None listed