Glioblastoom glioom
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • 18 years of age, or older • Subjected to a neurosurgical intracranial operation
Exclusion criteria
Exclusion criteria: - Participants of whom the required tissues cannot be accessed due to the operative route and strategy or of whom the tissue cannot be safely collected, including individuals of whom no autologous duraplasty can be harvested. - Individuals with inherent bleeding disorders. - Individuals with an inherent or acquired immunodeficiency and/or medications that suppress wound healing (except dexamethasone).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in (immune) cell composition (type of immune cells and abundance) and behaviour (as measured by gene and protein expression profiles and cell localization) of the meninges and skull bone marrow between patients with high-grade glioma and non-glioma controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| Tissues will be made part of a biobank. | — |
Countries
Netherlands
Outcome results
None listed