Stroke
Conditions
Interventions
cTBS treatment of the contralesional primary motor cortex
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a patient must meet all of the following criteria: - Age, 18 years or older; - First-ever unilateral ischemic stroke or intracerebral hemorrhage in a cerebral hemisphere or the brainstem; - Unilateral upper limb paresis with a motricity index between 9 and 99; - Inclusion possible between 3 weeks and 6 weeks after stroke onset; - Signed informed consent. In order to be eligible to participate in this study, a healthy control must meet all of the following criteria: - Age >= 18 years; - Normal motor function with a minimum Motricity Index (MI) of 99; - Signed informed consent.
Exclusion criteria
Exclusion criteria: - Upper limb paresis prior to stroke onset; - Absolute contra-indication to TMS: Magnetic sensitive objects implanted in the head or neck area (e.g. cochlear implants, implanted neurostimulator, pacemaker or defibrillator, metal splinters, metal fragments or metal clips), history of epilepsy, pregnancy or other contra-indications that may potentially be harmful as determined by the treating rehabilitation physician; - Incompetence or severe impairments that can impede study participation as determined by the treating rehabilitation physician (i.e. extreme fatigue, severe communication deficits); - Life expectancy shorter than one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Premovement interhemispheric inhibition from the contralesional to the ipsilesional primary motor cortex. | — |
Secondary
| Measure | Time frame |
|---|---|
| Interhemispheric inhibition from the contralesional to the ipsilesional primary motor cortex at rest TMS interference of the contralesional primairy motor cortex Intracortical inhibition of the contralesional primairy motor cortex (optional) | — |
Countries
Netherlands
Contacts
Public ContactJ.J.T Vink
Universitair Medisch Centrum Utrecht
Outcome results
None listed