Inflammatory Bowel Disease
Conditions
Interventions
The intervention is endoscopic sampling of the rectum, colon and ileum. The
only deviation from routine clinical practice is the cold snare biopsy of the
specific segment.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Inflammatory Bowel Disease (IBD) (Crohn*s disease (CD) or ulcerative colitis (UC)) patients who are planned to undergo a routine IBD colonoscopy with the collection of biopsies for disease activity assessment; >=18 years old; active disease (defined as Mayo>1 for UC or SES-CD>2 for CD); ability to provide informed consent.
Exclusion criteria
Exclusion criteria: Complete remission; history of colonic perforation during endoscopic procedures; active use of anticoagulant medications; familial history of bleeding disorders; known individual bleeding disorders; suspicion of dysplasia or colorectal carcinoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sample quality will be assessed based on the measure of cell yield, which quantifies the number of cells obtained in the biopsy samples. A higher cell yield typically indicates better sample quality, making it a key metric for evaluating the effectiveness of the biopsy procedures. In addition, the different cell types present in the biopsies will be analysed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Significant intra-procedural bleeding: as objectified by the endoscopist Post-procedural bleeding: defined as rectal blood-loss that requires re-colonoscopy: persistent bleeding (>2 days after procedure) Perforation (objectified on cross-sectional imaging) Infection: defined as formation of an abscess, appendicitis or peritonitis Other adverse events related to the biopsy procedure (abdominal pain, cramps) Patient discomfort | — |
Countries
Netherlands
Outcome results
None listed