Cerebrospinal fluid concentrations of polyols following traumatic brain injury

Cerebrospinal fluid concentrations of polyols following traumatic brain injury - SUGAR-TBI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56843

Enrollment

Registered

2024-06-13

Start date

2024-12-23

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurotrauma Traumatic brain injury

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Adult (aged at least 18 years) • Clinical diagnosis of moderate to severe TBI, classified by Glasgow Coma Scale (GCS), with GCS

Exclusion criteria

Exclusion criteria: • Admission to the ICU is solely for the purposes of palliative care or confirmation of organ donation • Advanced care directive or previously stated wish not to be included in research activities • Past medical history of diabetes mellitus • HbA1c >= 6.5%

Design outcomes

Primary

Measure	Time frame
i. CSF polyol (sorbitol and fructose) concentrations	—

Secondary

Measure	Time frame
i. CSF polyol : plasma glucose ratios. ii. CSF polyol : CSF glucose ratios. iii. Plasma and CSF neuroinflammatory markers: S100-beta, neuron specific enolase, neurofilament light, IL-6, TNF-alpha, Il-10, interferon-gamma.	—

Countries

Netherlands

Outcome results