The immune biological basis of severe fatigue after COVID-19 infection (IMMUNOFATIGUE)

The immune biological basis of severe fatigue after COVID-19 infection (IMMUNOFATIGUE) - A biological basis of post-COVID-19 fatigue

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56832

Enrollment

105

Registered

2021-01-23

Start date

2021-03-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 severe fatigue

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Post COVID-19 diagnosis (based on positive PCR or multidisciplinary team decision based on symptoms and CT or positive serology) • Referred for outpatient follow-up • Age >= 18 years • Provided written informed consent

Exclusion criteria

Exclusion criteria: • Unable or not willing to provide written informed consent • Unable to complete written questionnaires in Dutch • Living in a nursing home because of a diagnosis of dementia • Patients that visit the outpatient clinic in another hospital outside of the region

Design outcomes

Primary

Measure	Time frame
Gene expression profiles and inflammaging in monocytes of fatigued versus non-fatigued post-COVID patients	—

Secondary

Measure	Time frame
In fatigued versus non-fatigued post-COVID-19 patients Cellular immune parameters - Extensive immunophenotyping of monocyte maturation subsets - Extensive immunophenotyping of T-lymphocyte maturation subsets, including recently thymic emigrants - SARS-CoV2-specific CD8+ T-cell responses using immunodominant SARS-CoV-2 peptides Molecular parameters Next generation sequencing of the T-cell receptor repertoire	—

Measure

Time frame

In fatigued versus non-fatigued post-COVID-19 patients Cellular immune parameters - Extensive immunophenotyping of monocyte maturation subsets - Extensive immunophenotyping of T-lymphocyte maturation subsets, including recently thymic emigrants - SARS-CoV2-specific CD8+ T-cell responses using immunodominant SARS-CoV-2 peptides Molecular parameters Next generation sequencing of the T-cell receptor repertoire

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Countries

Netherlands

Outcome results