ouderdom en kwetsbaarheid mitochondrial dysfunction reduced metabolic capacity
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: > 65 years of age at start of the study Planned for elective surgery.
Exclusion criteria
Exclusion criteria: • Not able to read or speak Dutch or English; • Skin defects at the measurement side; • Mentally disabled; • Porphyria; • Presence of mitochondrial disease; • Medically unsave, or pfysically unable to perform a sit-to-stand test according to own justment or the justment of the medical staff or the research team assosiated with this studie
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary parameters are mitochondrial oxygen tension (mitoPO2), mitochondrial oxygen consumption (mitoVO2) and microcirculatory perfusion, with the latter encompassing total and perfused vessel density, proportion of perfused vessels, microvascular flow index, and vessel diameters | — |
Secondary
| Measure | Time frame |
|---|---|
| - MitoPO2 (mmHg). - MitoPO2 after extercise (1MSTS test) - metabolic frailty according the fried frailty phenotype assessment - Mitochondrial function in platelets. - Mitochondrial DNA in plasma as a marker of mitochondrial damage - Mitochondrial function in peripheral blood mononuclear cells - Post-operative complications - Length of hospital stay - Readiness for hospital discharge (using the RN-RHDS and the PT-RHDS) (30) - Postoperative factors: patient outcome (according to Clavien-Dindo complica-tion classification). (31) | — |
Countries
Netherlands
Outcome results
None listed