glucose intolerance Insulin resistance
Conditions
Interventions
Participants will be asked to consume once a 25g MCT-based nutrient mix, once a
25g MCT-based nutrient mix + cofactors, and once a non-ketogenic control
nutrient mix. Participants will be randomly a
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Aged 60-80 years - Body Mass Index (BMI) 25-35 kg/m2 - Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
Exclusion criteria
Exclusion criteria: - Type 2 diabetes - Pre-diabetes based on one or a combination of the following criteria: - Impaired Fasting Glucose (IFG): Fasting plasma glucose >= 6.1 mmol/l and 3 servings per day for man and >2 servings per day for woman - Unstable body weight (weight gain or loss > 5 kg in the last 3 months) - Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results - Significant food allergies/intolerance (seriously hampering study meals) - Participants who do not want to be informed about unexpected medical findings - Blood donation during or within 2 months prior to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study endpoint is plasma ketone levels (assessed via blood draws). | — |
Secondary
| Measure | Time frame |
|---|---|
| The explorative outcomes are energy expenditure (indirect calorimetry), substrate utilization (indirect calorimetry), plasma glucose (blood draw), plasma insulin (blood draw) and continuous interstitial ketone levels (continuous ketone monitor). | — |
Countries
Netherlands
Outcome results
None listed