schizophrenia spectrum disorders schizophrenia
Conditions
Interventions
Oral intake of nutritional drink (25g dGK versus isocaloric carbohydrate drink). Patients (n=28) will follow a crossover trial, and be randomised in a double-blind fashion to either intervention first
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with schizophrenia or bipolar disorder who are in at least partial remission receiving standard care able to give informed consent age 18 - 65 years old
Exclusion criteria
Exclusion criteria: Acute/florid psychosis, acute mania (unremitted) inability to give (informed) consent age < 18 or > 65 years old. liver function disorder kidney function disorder cardiovascular disease ketone body metabolism disorder diabetes pregnancy or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is percent change between intervention (dGK ingestion) vs control (isocaloric gold standard drink) in PPI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures include percent change between intervention and control drink: in basal EEG, P300 ERP, cognitive test scores; patient-experienced improvement in energy level, mood, ability to focus (visual analogue scale); metabolic and immune parameters (blood, sweat and saliva biomarkers; indirect calorimetry). | — |
Countries
Netherlands
Contacts
Public ContactK Huizer
Amsterdam UMC
Outcome results
None listed