Quantitative Magnetic Resonance imaging modalities in the assessment and determination of PORTAL hypertension study

Quantitative Magnetic Resonance imaging modalities in the assessment and determination of PORTAL hypertension study - MR PORTAL study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56775

Enrollment

Registered

2024-05-22

Start date

2024-11-23

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Increased portal pressure

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Patients with liver disease: • Patients of more than 18 years of age • Written informed consent • Patients with clinically proven portal hypertension due to chronic liver disease, either moderate (history of oesophageal varices grade 2/3 without use of beta-blockers as pharmaceutical treatment) or severe (recurrent oesophageal variceal bleeding, therapy-resistant ascites) Healthy controls: • Patients of more than 18 years of age • Written informed consent • No known liver disease by means of liver function test/ultrasound

Exclusion criteria

Exclusion criteria: - Absolute contraindications to MR imaging - Hepatocellular carcinoma or liver metastases

Design outcomes

Primary

Measure	Time frame
• The diagnostic accuracy of TMRE for assessing portal hypertension severity.	—

Secondary

Measure	Time frame
• Correlation of TMRE results (stiffness and viscosity) with HVPG pressure gradient measurements in patients with portal hypertension. • Correlation of TMRE results with US elastography measurements. • Correlation of TMRE results with ASL perfusion data. • Characterisation of TMRE in normalization of portal hypertension after medicinal or endovascular treatment. • The feasibility of novel synthetic MRI (SyMRI).	—

Measure

Time frame

• Correlation of TMRE results (stiffness and viscosity) with HVPG pressure gradient measurements in patients with portal hypertension. • Correlation of TMRE results with US elastography measurements. • Correlation of TMRE results with ASL perfusion data. • Characterisation of TMRE in normalization of portal hypertension after medicinal or endovascular treatment. • The feasibility of novel synthetic MRI (SyMRI).

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Countries

Netherlands

Outcome results