thermoregulation heat stress hyperthermia
Conditions
Interventions
Passive heat exposure (29-35ºC
6h/day for 7 days) in combination with
30min/day low-to-moderate intensity cycling.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy males and females 60 to 80 years BMI 25-30 kg/m2 Sedentary (
Exclusion criteria
Exclusion criteria: • Presence of uncontrolled chronic cardiovascular disease, as determined by medical history and physical examination • Participating in a structured exercise program • Taking hot baths/saunas regularly • Travelled for a prolonged time to destinations with elevated temperatures the last 3 months • Pre-existing T2DM • Blood donation within a month of study initiation • People with low hemoglobin concentration (males: Hb = 13.5-17.5 g/dL, females: Hb = 11.5-15.5 g/dL) • Recent participation in biomedical study (less than 1 month) • Using any medication that may influence glucose or lipid metabolism (beta-blockers, thyroid medications, stimulants, antidepressants, anticoagulants) • Smoking or abuse of alcohol • People with lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters include thermophysiological parameters (core temperature, skin temperature, and local sweat rate) and cardiovascular markers (heart rate, blood pressure, blood flow). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include metabolic parameters (substrate oxidation, energy expenditure, plasma glucose, insulin, total cholesterol, and free fatty acid concentrations), brain blood flow, endothelial function, and thermal perception (thermal sensation and comfort), and gastrointestinal tolerance. | — |
Countries
Netherlands
Outcome results
None listed