Circulating cell free DNA: the fingerprint of the Placenta

Circulating cell free DNA: the fingerprint of the Placenta - FIERCE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56768

Enrollment

Registered

2024-05-30

Start date

2024-07-31

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Placental disease

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: General: - Pregnant women >= 18 years and

Exclusion criteria

Exclusion criteria: Multiple pregnancy. - Gastro-intestinal diseases, heart diseases, liver, pancreas and kidney diseases. - Pre-existent diabetes mellitus. - Unable or unwilling to give informed consent. - Fetus with a known congenital/chromosomal abnormality.

Design outcomes

Primary

Measure	Time frame
To determine the methylation profiles of placental cell populations of: - uncomplicated pregnancies (controls). - inflammation in the placenta (cases).	—

Secondary

Measure	Time frame
- Identify underlying genes or genetic pathways related to identified methylation placental profiles of involved in (ab)normal placental development. - Define placental markers that can predict an abnormal inflamed placenta (chorioamnionitis and intervillositis).	—

Countries

Netherlands

Outcome results