Not applicable Not applicable
Conditions
Interventions
Not applicable because there are no interventions
Sponsors
Eureopean Commission
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - 18 y or higher age on the day of recruitment - Employment in a healthcare or animal research facility - Access to occupational healthcare provided by a certified service provider - Exposure to one of the following substance groups during at least two shifts per week: cytotoxics, inhalation anesthetics or hand disinfection products
Exclusion criteria
Exclusion criteria: - Persons who (at the time of the study) have a household member or who care for a patient receiving treatment with cytotoxics (at home or in hospital outpatient clinic)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytotoxics (urinary metabolite) * Cisplatrinum (urinary total platinum) * Carboplatinum (urinary total platinum) * Cyclophosphamide * 5-Fluoruracel (urinary alpha-fluoro-beta-alanine, FBAL) * Iphosphamide * Methotrexate * Doxorubicin * Gemcitabine * Docetaxel * Etoposide * Paclitaxel * Cytarabine Inhalation anaesthetics in end-exhaled air and urine (urinary metabolite) * Desflurane * Isofluorane * Nitrous oxide * Sevofluorane (trifluoroacetate, hexafluoro-isopropanol) Disinfection in end-exhaled air (urinary metabolite) * Ethanol * Isopropyl alcohol (acetone) | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition to aforementioned exposure biomarkers the following additional parameters will be studied: * Micronucleated peripheral blood lymphocyte (PBL-MN) * Micronucleated reticulocyte (RET-MN) * Micronucleated Buccal cells (B-MN) * Comets * Blood cell counts * Interleukines, IFN-gamma and TNF-alpha | — |
Countries
Czech Republic, Finland, France, Italy, Latvia, Luxembourg, Netherlands, Norway, Spain, United Kingdom
Contacts
Public ContactP.T.J. Scheepers
Radboud Universiteit Nijmegen
Outcome results
None listed