fundamental neuroscience in healthy adults normal brain function
Conditions
Interventions
Transcranial Ultrasonic Stimulation (TUS) aimed at bilateral mediodorsal
thalamus, and bilateral pulvinar thalamus (in separate sessions). Experimental
manipulations of (1) perceptual uncertainty an
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Between 18-40 years of age; - The ability and agreement to provide informed consent in sound body and mind, and the ability to fulfil the study*s requirements.
Exclusion criteria
Exclusion criteria: • Under 18 years of age; • Current pregnancy; • Claustrophobia; • A history or brain surgery or serious head trauma; • A history of or any close relatives (parents, siblings, children) with epilepsy, convulsion, or seizure; • Predisposition for fainting spells (syncope); • A cardiac pacemaker or intra-cardiac lines; • An implanted neurostimulator; • Implanted medication infusion device; • Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire), orjewellery/piercing that cannot be removed; • Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster); • Cochlear implants; • Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.); • Diagnosed neurological or psychiatric disorders; • Use of psychoactive (prescription) medication (excluding anti-conception); • Skin disease at intended stimulation sites; • The consumption of more than four alcoholic units within 24 hours before participation • The consumption of recreational drugs within 48 hours before participation; • Calcifications in the brain. • All other criteria relevant to non-invasive brain stimulation as reported in the Donders Standard Operating Procedures for Non-Invasive Brain Stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrinsic dynamics and task sensitivity of the cortical network partners of the stimulation targets (MD - prefrontal cortex, PUL - parietal cortex), estimated from electroencephalography (EEG) recordings, assess TUS effects. Changes in behavioural sensitivity to (1) perceptual and (2) task uncertainty manipulations following TUS application assess effects on decision computations. These are based on computational modelling of accuracy and response time measures. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will explore TUS-related changes in physiological arousal based on measured of heart rate and pupil size. Anatomical MRI measurements will be acquired to perform personalized simulations of ultrasonic wave propagation; functional MR images will be used to test the dissociable involvement of the targeted thalamocortical networks in the decision task. | — |
Countries
Netherlands
Outcome results
None listed