Acute necrotizing pancreatitis
Conditions
Interventions
Implementation of a best-practice protocol on cluster level, targeted at 
clinical staff involved in the treatment of necrotizing pancreatitis. During a 
two-month transition phase, intervention clusters will engage in the 
implementation procedure including educational and consensus meetings, an 
e-learning platform and clinical decision tool. The best-practice protocol 
consists of recommendations to improve and standardize the antimicrobial 
treatment strategy for necrotizing pancreatitis. These recommendations are 
based on antimicrobial stewardship principles, the best available evidence and 
a worldwide Delphi consensus survey. A final component of the intervention is 
the evaluation of the implementation strategy and assessment of compliance with 
the best-practice protocol.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >= 18 years - Hospitalized patient diagnosed with acute pancreatitis according to the revised Atlanta classification - Signs of pancreatic or peripancreatic necrosis on imaging - Written informed consent
Exclusion criteria
Exclusion criteria: - Patients with a current pancreatic carcinoma - Patients with (an acute flare-up of) chronic pancreatitis according to the M-ANNHEIM criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is a composite of mortality and major complications between index admission and 6 months follow-up. Major complications are defined as new onset organ failure and necessity of invasive intervention(s) for infected pancreas necrosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include antimicrobial use, infections with multi-drug resistant microorganisms, development of major infections and other complications, health care utilization, quality of life and cost-effectiveness. | — |
Countries
Netherlands
Outcome results
None listed