Major Depressive Disorder
Conditions
Interventions
Future-oriented imaginary rescripting (ImRes): ImRes is an imagery technique in
which patients change a negative image in a positive way. These negative
future-oriented mental images (for example im
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 years or older ; 2) Meet DSM-5 criteria for major depressive disorder; 3) Be able to understand questionnaires and study information letter; 4) In case of medication use: are stable on medication for six weeks or longer; 5) Presence of at least one negative future-oriented mental imagery, which causes distress.
Exclusion criteria
Exclusion criteria: 1) Psychosis and/or bipolarity 2) Severe cognitive impairment (e.g., mental retardation) as evidenced by clinical impression; 3) Current EMDR or imagery rescripting therapy 4) Other circumstances that might affect participation (e.g., severe medical disorder, relocation).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this pilot study is to test the acceptability of imagery rescripting. | — |
Secondary
| Measure | Time frame |
|---|---|
| • To measure feasibility, we will assess recruitment/admission ratio, dropout and (serious) adverse events. • To estimate the variance of effects, group effects on depressive symptoms measured with the BDI-II and SCID-5-s (module A)will be tested at post-treatment and 3 months follow-up (corrected for baseline). • Screening for other disorders (SCID-5 Dutch version); sections on depressive disorder, substance use disorder, psychotic disorders, anxiety disorders andposttraumatic disorder • Behavioral activation (Behavioral Activation for Depression Scale - Dutch version) • Affect: The International Short-form of the Positive and Negative Affect Schedule (I-PANAS-SF) • Quality of life (EQ-5D-5L) • Anxiety measured with Generalized Anxiety Disorder scale (GAD-7) • Vividness and likelihood of prospective positive and negative scenarios with prospective imagery task (PIT) • Ratings of mental images on emotions (sad, guilty, ashamed, anxious, angry, helpless), vivedness, uncontrollability, distress and core belief, using 0-100 visual analog scales ranging • Monitoring of treatment as usual will be asked to the therapist at baseline (*which treatment (including medication + dose; possible in-patient treatment) does the patient receive currently?') and at posttreatment and follow-up ("which therapy has the patient received in the past 6/12 weeks (including medication + dose; possible in-patient treatment)?") | — |
Countries
Netherlands
Outcome results
None listed