Assessment of the alignment of the Atlas and surrounding tissues in chronic whiplash associated disorder.

Assessment of the alignment of the Atlas and surrounding tissues in chronic whiplash associated disorder. - MRAtlas

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56685

Enrollment

Registered

2023-07-13

Start date

2024-10-08

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Whiplash, neck sprain

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Phase 1  Control participants • Healthy individuals  • Ability to follow test instructions • Aged between 18 - 75 years Phase 2  Chronic Whiplash Associated Disorder • Healthy individuals  • Ability to follow test instructions • WAD 1 or 2 Diagnosis • Aged between 18 - 75 years • Individuals who are planning to start physiotherapy Chronic headache • Healthy individuals  • Ability to follow test instructions • Diagnosis chronic headache • Aged between 18 - 75 years • Individuals who are planning to start physiotherapy

Exclusion criteria

Exclusion criteria: • Inability to provide informed consent • Have a history of claustrophobia • Patient/ participant is not eligible to follow instructions • Contra-indication for MRI (e.g., pacemaker, Claustrophobia; See F1 vragenlijsten screening MRI Amsterdam UMC) • Being under investigation for non-diagnosed disease at the time of investigation

Design outcomes

Primary

Measure	Time frame
The main primary endpoints are the repeatability of the assessment of the position and alignment of the Atlas (C1) as measured by the angles between the atlas and the surrounding vertebrae in healthy control participants, and the difference in atlas geometry between the two patient groups and the healthy control participants.	—

Secondary

Measure	Time frame
Secondary endpoints include the assessment of the fat percentage of the suboccipital muscles and the blood flow in the carotid and vertebral arteries, as well as the quantification of differences between the groups. The study's secondary endpoint is established through a neurological examination, physical asymmetry test and questionnaires. Questionnaires are utilized to obtain a quantitative indication of participants' pain experiences, subsequently allowing correlation with the position of the atlas. Additionally, the differences in all these parameters between before and after physiotherapy will be quantified.	—

Measure

Time frame

Secondary endpoints include the assessment of the fat percentage of the suboccipital muscles and the blood flow in the carotid and vertebral arteries, as well as the quantification of differences between the groups. The study's secondary endpoint is established through a neurological examination, physical asymmetry test and questionnaires. Questionnaires are utilized to obtain a quantitative indication of participants' pain experiences, subsequently allowing correlation with the position of the atlas. Additionally, the differences in all these parameters between before and after physiotherapy will be quantified.

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Countries

Netherlands

Contacts

Public ContactA.J. Nederveen

Amsterdam UMC

a.j.nederveen@amsterdamumc.nl020-5668368

Outcome results