ovarian carcinoma
Conditions
Interventions
None listed
Sponsors
Catharina-ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Subjects should be at least 18 years old and mentally competent -Newly diagnosed patients with ovarian carcinoma (OC) who go for primary debulking surgery or patients with OC are scheduled for interval debulking - Controls: women who undergo surgery for benign gynaecological conditions under general anaesthesia
Exclusion criteria
Exclusion criteria: -Mentally incompetent -Pregnant or breastfeeding -Known inflammatory or infectious diseases or an immunosuppressive status -Using medication interfering with the immune system -Severe comorbidities: other active malignancy (except for basal cell carcinoma and other in situ carcinomas) -Serious psychiatric pathology -A self-reported alcohol consumption of >21 units per week -Bleedings disorder -History of splenectomy -Not mastering the Dutch language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterizing the immune status of ovarian carcinoma patients compared to cancer-free controls, with a focus on hematopoietic organs and the immune cells originating from them. This will be accomplished by assessing the transcriptional, epigenetic, and functional programming of circulating monocytes and myeloid precursor cells in OC. | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed