Onderzoek naar de functionaliteit en gezondheid van de dunne darm in mensen met obesitas. Intestinal functionality and health intestinal health
Conditions
Interventions
None listed
Sponsors
Rijnstate Ziekenhuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Patients with the age of 18 or older - BMI > 40 kg/m2 - BMI > 35 en < 40, with a obesity related comorbidity of which is suspected that it improves after surgery induced weight loss.
Exclusion criteria
Exclusion criteria: no exlcusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of this study is to determine transport functionality, integrity, and viability in each intestinal biopsy. The transport functionality is shown as the ratio of transcellular to paracellular transport, also called the Papp ratio (Papp = Apparent permeability rate). Permeability of FITC-Dextran (4000 Dalton, FD4) determines intestinal integrity, and secretion of lactate dehydrogenase (LDH) determines tissue viability. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition to these primary endpoints, processes that play an important role in intestinal and overall health will also be measured in each biopsy. This includes: 1) absorption and metabolism of foods and medicines, 2) (influencing) intestinal permeability, 3) release of satiety hormones, 4) local immunological reactions, and 5) interaction with the intestinal microbiome. | — |
Countries
Netherlands
Outcome results
None listed