Parkinson's diseasei/rigidity and slowness in movement
Conditions
Interventions
Patients will undergo an additional MEG scan.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Adult patients (Parkinson's disease and essential tremor) with DBS therapy for a minimum of six months -Have undergone a preoperative 7-Tesla MRI scan
Exclusion criteria
Exclusion criteria: Legally incompetent adults and no written informed consent A spinal stimulation or deep brain stimulation system is not compatible with 7-Tesla MRI There a no implants inadmissible in the MEG, although patients will be questioned for possible (non-removable) implants such as pacemaker and/or dental as they may interfere with the magnetic signals
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is change in motor skills measured by the UPDRS-III/TETRAS and in quality of life by the PDQ-30 (co-primary outcomes) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures are the Amsterdam Linear Disability Score for functional health status, Parkinson*s Disease Questionnaire 39 (PDQ-39), Starkstein apathy scale, Quality of Life Questionnaire in Essential Tremor (QUEST), patient satisfaction with the treatment, patient evaluation of treatment burden, change of tremor medication, side effects and complications. | — |
Countries
Netherlands
Outcome results
None listed