Recovery after community acquired pneumonia in children: The short and long-term consequences

Recovery after community acquired pneumonia in children: The short and long-term consequences - Recovery after pneumonia: RAP-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56675

Enrollment

250

Registered

2024-01-02

Start date

2024-04-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

community acquired pneumonia lower respiratory tract infection

Interventions

None listed

Eligibility

Age

No minimum to 15 Years

Inclusion criteria

Inclusion criteria: • Children >= 4 weeks -

Exclusion criteria

Exclusion criteria: Severe concomitant disease Nosocomial infection Language barrier

Design outcomes

Primary

Measure	Time frame
- Time to complete recovery from CAP. Complete recovery is defined as the child returned to his/her normal state of health, as reported by parents. - Duration of symptoms at follow up: cough, wheezing, problems with sleeping, gastrointestinal complaints, problems with eating, fatigue, dyspnea and upper respiratory tract symptoms.	—

Secondary

Measure	Time frame
- Association between demographic, clinical and microbial factors on still having persistent symptoms at 3 months following hospital admission - Influence of demographic, clinical and microbial factors on recurrence of CAP or other LRTI*s following hospital admission. - Cardiac function as assessed by left systolic ventricular function, right systolic ventricular function and serum NT-proBNP and Troponin-T. - Respiratory and gut microbiome composition including viral presence and abundance in children hospitalized for a CAP, on admission, after 5-7 days and after 4-6 weeks. - Presence or absence of a pneumococcal bacteria in children hospitalized for a CAP, on admission and after 4-6 weeks. - The nasal inflammatory profile, in children diagnosed with CAP, on admission and after 4-6 weeks. - Questionnaires for possible influences of demographic, clinical and microbial factors on persisting symptoms and QoL in children after CAP infection. - Quantifying disease recovery by measuring 24-hour movement behaviour using two accelerometers, one on the hip and one on the wrist, after admission and after 4-6 weeks.	—

Measure

Time frame

- Association between demographic, clinical and microbial factors on still having persistent symptoms at 3 months following hospital admission - Influence of demographic, clinical and microbial factors on recurrence of CAP or other LRTI*s following hospital admission. - Cardiac function as assessed by left systolic ventricular function, right systolic ventricular function and serum NT-proBNP and Troponin-T. - Respiratory and gut microbiome composition including viral presence and abundance in children hospitalized for a CAP, on admission, after 5-7 days and after 4-6 weeks. - Presence or absence of a pneumococcal bacteria in children hospitalized for a CAP, on admission and after 4-6 weeks. - The nasal inflammatory profile, in children diagnosed with CAP, on admission and after 4-6 weeks. - Questionnaires for possible influences of demographic, clinical and microbial factors on persisting symptoms and QoL in children after CAP infection. - Quantifying disease recovery by measuring 24-hour movement behaviour using two accelerometers, one on the hip and one on the wrist, after admission and after 4-6 weeks.

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Countries

Netherlands

Outcome results