Muscle and skin research (no disorders) muscle skin
Conditions
Interventions
One leg of the subjects will receive LLLT, while the other leg will receive no
treatment. After the treatment muscle and skin biopsy samples will be taken
from both legs.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Male or female sex • Aged between 18 and 35 y inclusive • BMI between 18.5 and 30 kg/m2
Exclusion criteria
Exclusion criteria: • Participating in a structured (progressive) exercise program or >4h of vigorous physical activity per week. • Smoking regularly (i.e. >5 cigarettes/week) • Pregnancy • Hormonal replacement therapy • Diagnosed musculoskeletal disorders • Diagnosed metabolic disorders (e.g. diabetes) • Diagnosed skin disorders • Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories). • Chronic use of anti-coagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be mitochondrial respiration of the LLLT treated and non-treated leg based on muscle samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are muscle and skin gene expression, protein signalling and enzyme activity. | — |
Countries
Netherlands
Outcome results
None listed