Acute respiratory failure
Conditions
Interventions
The treatment intervention is a pre-specified switch from controlled to
assisted ventilation when PaO2/FiO2 ratio reaches >= 200 mmHg.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • At least 18 years old • Written informed consent • Mechanical ventilation via an endotracheal tube • Acute hypoxemic respiratory failure with PaO2/FiO2 ratio
Exclusion criteria
Exclusion criteria: • Expected mechanical ventilation duration of 0.5 gamma) and/or fluids, and/or heart rate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the change in regional lung stress when switching from controlled to assisted ventilation and until a successful or failed switch. This will be derived from electrical impedance tomography (EIT) recordings by computing the ventilation distribution (parameter reflecting lung and ventilation inhomogeneity). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include other EIT-derived parameters, lung tissue characteristics on PCCT scan, respiratory mechanics, breathing effort, ventilator-free days, patient-ventilator interaction, gas exchange and hemodynamics, and inflammatory biomarkers. | — |
Countries
Netherlands
Contacts
Public ContactA.H. Jonkman
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed