MS multiple sclerosis
Conditions
Interventions
None listed
Sponsors
Zuyderland Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with relapsing-remitting MS (
Exclusion criteria
Exclusion criteria: Patients who are 65 years old Patients who presented first clinical event more than five years ago Patients who have already started DMT Patients who are incapable of giving informed consent Patients who are unable to undergo local MRI scan, due to for instance: Physical problems, for instance due to size/obesity (not fitting in regular MRI scanner), not being able to lie flat for extended periods of time (e.g. due to pain, shortness of breath). Due to claustrophobia. Patients who have contraindications for MRI scan, for instance due to MRI-unsafe or non-compatible implanted material/devices, such as pacemakers or ocular metal splinters, or patients who are pregnant at inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. What is the incidence of asymptomatic spinal cord lesions in patients commencing DMT? 2. In the absence of radiological progression on brain imaging, how frequently do asymptomatic spinal cord lesions occur? In other words, how often is disease activity solely proven by spinal cord MRI and what is the number-needed-to-scan? | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include which patient subgroups are prone to new spinal cord lesions at follow-up in early disease. | — |
Countries
Netherlands
Outcome results
None listed