Ipsilateral recidive or second primary mammacarcinoma Recurrent breast cancer or second new tumor in the same breast
Conditions
Interventions
The intervention involves preoperative accelerated partial re-irradiaton 
followed by repeat breast conserving surgery.
Sponsors
Antoni van Leeuwenhoek (AVL)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Female patients >= 51 years • Ipsilateral breast cancer; recurrence or second primary • Either histologically proven invasive adenocarcinoma (invasive adenocarcinoma with DCIS component is also accepted) or DCIS alone (calcification associated on imaging) • Histologically proven estrogen receptor positive • HER2neu negative • In case of invasive adenocarcinoma: tumor size <= 3 cm. In case of DCIS alone: affected area <= 2.5 cm • Grade I or grade II (biopsy) • cN0M0 • Unifocal lesions on mammogram and MRI • Interval since completion of local treatment of primary tumor > 12 months • Previous radiotherapy (whole breast or partial) of the ipsilateral breast • Repeat breast conserving surgery feasible
Exclusion criteria
Exclusion criteria: • >= grade 3 radiotherapy toxicity in the breast • Distant metastases and/or synchronous contralateral invasive or in situ carcinoma • Lobular invasive carcinoma or pleiomorph LCIS • ER negative subtype • Lymphovascular invasion in biopsy • Neoadjuvant systemic treatment for the protocol tumor (except for admission of pre-surgery hormonal therapy <= 2 months) • (Planned) oncoplastic surgery with major tissue displacement• BRCA mutations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute post-treatment toxicity up to 3 months after end of local treatment, assessed by the CTCAE v5.0. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Fibrosis/induration • Quality of life • Cosmetic outcome according to the BCCT.core software program | — |
Countries
Netherlands
Contacts
Public ContactA. Scholten
Antoni van Leeuwenhoek (AVL)
Outcome results
None listed