COVID 19 ARDS shocklong
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Adult (male >= 20 years of age and female >= 20 years of age) patients • Mechanically ventilated • Patient meets the criteria for non-resolving ARDS as at day 5 of the ARDS diagnosis one or more of the following criteria is true: o P/F ratio = 20 years of age and female >= 20 years of age) patients • Mechanically ventilated • Patient meets the criteria for non-resolving ARDS as SARS-CoV-2 PCR CT >30 and one or more of the following criteria is true: o P/F ratio
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • Women who are pregnant or breastfeeding • Inability to attain informed consent • Too unstable for transport as judged by the treating staff intensivist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To quantify pulmonal fibroblast activity via [68Ga]-FAPI PET in non-resolving ARDS patients in the ICU and the relation with disease specific survival, length of stay at the ICU and ventilator free days at day 28. | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the relationship between pulmonal [68Ga]-FAPI uptake and systemic blood markers of inflammation and extracellular matrix remodelling. | — |
Countries
Netherlands
Outcome results
None listed