Osteoporose
Conditions
Interventions
Participants will take one dose of oral probiotic or placebo daily for 12
weeks. The daily dose will consist of 1 sachet of 4 gram probiotics or placebo
per day dissolved in 200 ml luke warm water.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Adult renal transplant recipient >1 year post transplantation 2. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. Renal transplant recipient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in vitamin K status as assessed by plasma dp-ucMGP between the 2 groups after 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine the effect of a daily sachet of 4 gram freeze-dried probiotics producing 180 µg vitamin K2 in 24-hour urine on vitamin K metabolites 5C and 7C-aglycone, and vitamin K1 and MK4 and MK-7 in stool samples after 12 weeks in participants. 2. Impact of the probiotic on the composition of the gut microbiome. 3. Assess the affect of the probiotic on serum markers for low grade inflammation (high-sensitivity C-reactive protein) and endothelial dysfunction (soluble vascular endothelium adhesion molecule 1 and soluble intercellular adhesion molecule 1) will also be assessed | — |
Countries
Netherlands
Outcome results
None listed