Research on the mechanism of cognitive decline in patients after cerebellar pontine angle tumour surgery

Research on the mechanism of cognitive decline in patients after cerebellar pontine angle tumour surgery - Cognitive impairments after CPA surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56566

Enrollment

Registered

2023-08-22

Start date

2025-01-13

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebellar pontine angle tumour, vestibular schwannoma, meningioma

Interventions

No intervention. All patients will undergo extensive neuropsychological testing, followed by a MRI scan.&nbsp

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients diagnosed with a cerebellar pontine angle tumour (Koos  classification grade 4 vestibular schwannoma or large meningioma) that have been operated in the past. - Control population consisting of patients with unilateral hearing loss due to  a cerebellar pontine angle tumour Koos classification grade 4 or large meningioma. These control  patients have a ‘wait and see’ policy with annual follow up and did not have  surgery in the past. Control patients will be matched (as far as possible) to  the study population on Koos grade, age, level of education, hearing loss and  tumour side. - >= 18 years of age - Dutch proficiency

Exclusion criteria

Exclusion criteria: - contra-indication for MR imaging - history of neurofibromatosis type II - history of cerebellopontine angle surgery or Gamma Knife radiation - secondary hydrocephalus due to surgery - concurrent neurological or psychiatric illness - not able to give informed consent

Design outcomes

Primary

Measure	Time frame
The main study parameters of this study are: - patient variables (age, sex, level of education, unilateral hearing loss, tinnitus). - tumour parameters (diameter, volume, side, etc). - surgical parameters (length of operation, blood loss, etc). - neuropsychological testing and/or its different domains - CCAS/Schmahmann scale. - MR Imaging findings (degree of oedema, anatomical displacement, etc). - DWI findings (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), etc). The primary outcome measures are: - scores on the different domains of extensive neuropsychological testing - scores on CCAS/Schmahmann scale - abnormalities on tractography	—

Measure

Time frame

The main study parameters of this study are: - patient variables (age, sex, level of education, unilateral hearing loss, tinnitus). - tumour parameters (diameter, volume, side, etc). - surgical parameters (length of operation, blood loss, etc). - neuropsychological testing and/or its different domains - CCAS/Schmahmann scale. - MR Imaging findings (degree of oedema, anatomical displacement, etc). - DWI findings (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), etc). The primary outcome measures are: - scores on the different domains of extensive neuropsychological testing - scores on CCAS/Schmahmann scale - abnormalities on tractography

—

Secondary

Measure	Time frame
The secondary outcome measures are: - additional MR Imaging findings in correlation to neuropsychological testing.	—

Countries

Netherlands

Contacts

Public ContactM Ter Laan

Radboud Universitair Medisch Centrum

mark.terlaan@radboudumc.nl024-3616604

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)