colorectal liver metastases metastases in the liver from primary colon cancer
Conditions
Interventions
Preoperative
Patients will receive a single dose of 10 mg, 20 mg or 0,5 mg/kg of indocyanine
green (ICG) 1 to 7 days prior to surgery.
Intraoperative
The standard surgical procedure will be perform
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Receiving open or robotic surgery for (multiple) colorectal liver metastases • Eligible for indocyanine green infusion • Pretreated with neoadjuvant chemotherapy (received last cycle of chemotherapy within 3 months before surgery) • Received at least 3 cycles of chemotherapy • Above 18 years of age
Exclusion criteria
Exclusion criteria: • Diagnosed with anything other than colorectal liver metastases after histological examination • Known allergy to indocyanine green • Known allergies to shells and/or clamps • Receiving other types of surgery then open and robotic surgery • Contraindication for indocyanine green (EGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Back-table signal-to-background ratio in bread loaves | — |
Secondary
| Measure | Time frame |
|---|---|
| Back-table mean fluorescence intensity of signal fluorescence in bread loaves Back-table mean fluorescence intensity of background fluorescence in bread loaves Back-table width of the fluorescent *rim* in bread loaves In vivo signal-to-background ratios Radical resection rates Intraoperative visibility of the lesion(s) based on intraoperative questionnaires - For robotic surgery: Difference between interpretability of the fluorescence in *normal* Firefly mode and in *sensitive* Firefly mode based on intraoperative questionnaires. IHC scoring of Chemotherapy Associated Liver Injury (CALI) and liver function blood analysis Lifetime imaging, IHC, and bread loaf fluorescence correlation | — |
Countries
Netherlands
Outcome results
None listed